FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\LRRK2R1441C.UAS.cIa.Tag:FLAG
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General Information
Symbol
Hsap\LRRK2R1441C.UAS.cIa.Tag:FLAG
Species
H. sapiens
Name
FlyBase ID
FBal0326149
Feature type
allele
Associated gene
Hsap\LRRK2
Associated Insertion(s)
Carried in Construct
P{UAS-hLRRK2.R1441C.I.FLAG}
Key Links
Transgenic product class
missense_variant
(Islam et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Islam et al., 2016)
Mutagen
in vitro construct
(Islam et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-hLRRK2.R1441C.I.FLAG}
Cytology
Description

UAS regulatory sequences drive expression of Hsap\LRRK2 cDNA with a mutation in the GTPase domain (R1441C), fused with an N-terminal Tag:FLAG tag.

(Islam et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\LRRK2
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease
      CEA
      (Islam et al., 2016)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Islam et al., 2016)
      LRRK2:p.Arg1441Cys
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      ClinVar: LRRK2_1938
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\LRRK2R1441C.Scer\UAS.cIa.T:Zzzz\FLAG under the control of Scer\GAL4GMR.PU leads rapid age-progressive photoreceptor degeneration in the adult eye leading to visible disorganization of the surface ommatidial array.

      Adult flies expressing Hsap\LRRK2R1441C.Scer\UAS.cIa.T:Zzzz\FLAG under the Scer\GAL4Ddc.PL driver are short lived, show a steeper age-related decline of climbing ability and aged flies (6-week-old) display significantly reduced number of dopaminergic neurons from the PPM1/2 cluster compared to controls and a complete loss of PPL1, PAL and PPL2ab neurons, whereas the number of neurons in the PAM and PPM3 clusters is not significantly affected.

      (Islam et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\LRRK2R1441C.Scer\UAS.cIa.T:Zzzz\FLAG
      Hsap\LRRK2R1441C.UAS.cIa.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (2)