FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cic::HsapDUX4UAS.cFa
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General Information
Symbol
Dmel\cic::Hsap\DUX4UAS.cFa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Fores
FlyBase ID
FBal0326593
Feature type
allele
Associated gene
cic::Hsap\DUX4
Associated Insertion(s)
Carried in Construct
P{UAS-cic::hryDUX4.F}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Forés et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-cic::hryDUX4.F}
Cytology
Description

UASt regulatory sequences drive expression of a chimeric protein consisting of most of cic (amino acids 1-1380) including the C1 domain, fused to the C-terminal portion (amino acids 325-424) of Hsap\DUX4. The composition of this chimeric protein mirrors oncogenic CIC-DUX4 fusion chimeras associated with Ewing-like sarcomas in humans.

(Forés et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
cic::Hsap\DUX4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Forés et al., 2017)
      CIC/DUX4_fusion
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      t(4;19)(q35;q13.1) CIC/DUX4
      Associated human disease model(s)
      External database links
      COSMIC_fusion: CIC-DUX4
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of cic::Hsap\DUX4Scer\UAS.cFa under the control of Scer\GAL4cv-c-C5 causes severe defects including reduced wing size, ectopic venation and blistered wings.

      (Forés et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      cic::Hsap\DUX4Scer\UAS.cFa
      cic::Hsap\DUX4UAS.cFa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Fores
      Secondary FlyBase IDs
        References (2)