FlyBase Allele Report: Dmel\ato[SA-KI]

General Information

Symbol

Dmel\ato^SA-KI

Species

D. melanogaster

Name

FlyBase ID

FBal0326611

Feature type

allele

Associated gene

Dmel\ato

Associated Insertion(s)

TI{TI}ato^SA-KI

Carried in Construct

Key Links

Allele class

Mutagen

phiC31 integrase

Nature of the Allele

Allele class

Mutagen

phiC31 integrase

(Quan et al., 2016)

Progenitor genotype

Associated Insertion(s)

TI{TI}ato^SA-KI

Cytology

Description

The endogenous ato locus has been replaced with a mutated form of ato in which the highly conserved proneural phosphorylation site is changed from Ser to Ala (non-phosphorylatable mutation). Generated by the IMAGO knockin approach.

(Quan et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage

(Quan et al., 2016)

abnormal size | adult stage

(Quan et al., 2016)

visible | adult stage

(Quan et al., 2016)

Phenotype Manifest In

eye

(Quan et al., 2016)

eye photoreceptor cell

(Quan et al., 2016)

interommatidial bristle

(Quan et al., 2016)

ommatidium

(Quan et al., 2016)

Detailed Description

Statement

Reference

ato^SA-KI mutant adults show defects in eye morphology - smaller eyes with ommatidia of uneven size, missing and disorganized interommatidial bristles and loss of photoreceptor neurons (number of which range from two to seven per ommatidium) as well as photoreceptor cell-fate determination defects.

(Quan et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ato^SA-KI has abnormal neuroanatomy | adult stage phenotype, enhanceable by Egfr[+]/Egfr^f2

(Quan et al., 2016)

Phenotype Manifest In

Enhanced by

Statement

Reference

ato^SA-KI has eye photoreceptor cell phenotype, enhanceable by Egfr[+]/Egfr^f2

(Quan et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The reduced number of photoreceptor neurons per ommatidium characteristic for ato^SA-KI mutants is further decreased by combination with a single copy of Egfr^f2 and majority of the ommatidia contain only the R8 photoreceptor cell.

(Quan et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ato^SA-KI

(Quan et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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