FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Mmus\Kctd2UAS.Tag:MYC
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General Information
Symbol
Mmus\Kctd2UAS.Tag:MYC
Species
M. musculus
Name
FlyBase ID
FBal0327006
Feature type
allele
Associated gene
Mmus\Kctd2
Associated Insertion(s)
Carried in Construct
P{UAS-mKctd2.Myc}
Transgenic product class
cDNA
(Li et al., 2017)
wild_type
(Li et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Li et al., 2017)
wild_type
(Li et al., 2017)
Mutagen
in vitro construct
(Li et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-mKctd2.Myc}
Cytology
Description

UAS regulatory sequences drive expression of Mmus\Kctd2 cDNA (GenBank accession NM_183285.3), fused at the N-terminal with 1xTag:MYC.

(Li et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Mmus\Kctd2
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult flies expressing Mmus\Kctd2Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav-C155 show a moderate increase in the total amount of nighttime sleep, the sleep bout length is increased while their number is reduced and total daytime sleep is comparable to controls.

      (Li et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Mmus\Kctd2UAS.Tag:MYC/Scer\GAL4inc.PS is a suppressor | partially of abnormal sleep | adult stage phenotype of inc1

      (Li et al., 2017)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The sleep deficit (reduced total amount of both daytime and nighttime sleep, along with short sleep bout length with increased bout number) characteristic for inc1 mutant adults can be partially rescued by Scer\GAL4inc.PS-driven expression of Mmus\Kctd2Scer\UAS.T:Hsap\MYC in the mutant background.

      (Li et al., 2017)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mmus\Kctd2Scer\UAS.T:Hsap\MYC
      Mmus\Kctd2UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)