FlyBase Allele Report: Dmel\sav[S413A.UAS]

General Information

Symbol

Dmel\sav^S413A.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0327415

Feature type

allele

Associated gene

Dmel\sav

Associated Insertion(s)

Carried in Construct

P{UAS-sav.S413A}

Key Links

Transgenic product class

missense_variant

(Wehr et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Wehr et al., 2013)

Mutagen

in vitro construct

(Wehr et al., 2013)

Progenitor genotype

Carried in construct

P{UAS-sav.S413A}

Cytology

Description

UAS regulates expression of an activated form of sav (containing a mutation for a regulatory Sik2 site S413A).

(Wehr et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

sav

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^rn.PU

(Aerne et al., 2015)

Phenotype Manifest In

wing, with Scer\GAL4^rn.PU

(Aerne et al., 2015)

Detailed Description

Statement

Reference

The expression of sav^{S413A.Scer\UAS} under the control of Scer\GAL4^rn.PU leads to a significant decrease in wing area, as compared to controls.

(Aerne et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^rn.PU, sav^S413A.UAS has abnormal size | adult stage phenotype, suppressible | partially by Herc4^UAS.cAa, Scer\GAL4^rn.PU

(Aerne et al., 2015)

NOT suppressed by

Statement

Reference

Scer\GAL4^rn.PU, sav^S413A.UAS has abnormal size | adult stage phenotype, non-suppressible by Herc4^C-A.UAS, Scer\GAL4^rn.PU

(Aerne et al., 2015)

Scer\GAL4^rn.PU, sav^S413A.UAS has abnormal size | adult stage phenotype, non-suppressible by Herc4^C6.3/Herc4^C6.3

(Aerne et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^rn.PU, sav^S413A.UAS has wing | adult stage phenotype, suppressible | partially by Herc4^UAS.cAa, Scer\GAL4^rn.PU

(Aerne et al., 2015)

NOT suppressed by

Statement

Reference

Scer\GAL4^rn.PU, sav^S413A.UAS has wing | adult stage phenotype, non-suppressible by Herc4^C-A.UAS, Scer\GAL4^rn.PU

(Aerne et al., 2015)

Scer\GAL4^rn.PU, sav^S413A.UAS has wing | adult stage phenotype, non-suppressible by Herc4^C6.3/Herc4^C6.3

(Aerne et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The decreased wing area resulting from the expression of sav^{S413A.Scer\UAS} under the control of Scer\GAL4^rn.PU is partially suppressed by the co-expression of Herc4^Scer\UAS.cAa but not by the co-expression of Herc4^C-A.Scer\UAS or by the Herc4^C6.3 homozygosity.

(Aerne et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sav^{S413A.Scer\UAS}

sav^S413A.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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