FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\MAPTMARK1S6E.UAS.2N4R
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General Information
Symbol
Hsap\MAPTMARK1S6E.UAS.2N4R
Species
H. sapiens
Name
FlyBase ID
FBal0327431
Feature type
allele
Associated gene
Hsap\MAPT
Associated Insertion(s)
Carried in Construct
PBac{UAS-hMAPT.MARK1S6E.2N4R}
Key Links
Transgenic product class
missense_variant
(Fernius et al., 2017)
polypeptide_post_translational_processing_variant
(Fernius et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Fernius et al., 2017)
polypeptide_post_translational_processing_variant
(Fernius et al., 2017)
Mutagen
in vitro construct
(Fernius et al., 2017)
Progenitor genotype
Carried in construct
PBac{UAS-hMAPT.MARK1S6E.2N4R}
Cytology
Description

UAS regulatory sequences drive expression of the Hsap\MAPT 2N4R isoform, with S-to-E amino acid replacements in 6 residues to mimic phosphorylation by Hsap\MARK1 (S262E, S293E, S305E, S320E, S324E, S356E).

(Fernius et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\MAPT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\MAPTMARK1S6E.Scer\UAS.2N4R under the control of Scer\GAL4nSyb.PS combined with tub-Gal800[ts] to limit the expression to adulthood leads to moderately but significantly reduced adult lifespan.

      (Fernius et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The reduced adult lifespan caused by expression of Hsap\TTBK1Scer\UAS.T:Hsap\MYC,T:Ivir\HA1 is also exacerbated by co-expression of Hsap\MAPTTTBK1S6A.Scer\UAS.2N4R.

      (Fernius et al., 2017)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\MAPTMARK1S6E.Scer\UAS.2N4R
      Hsap\MAPTMARK1S6E.UAS.2N4R
      hTauMARK1S6E
      (Fernius et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)