FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ir40a1
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General Information
Symbol
Dmel\Ir40a1
Species
D. melanogaster
Name
FlyBase ID
FBal0327459
Feature type
allele
Associated gene
Dmel\Ir40a
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Silbering et al., 2016)
Mutagen
CRISPR/Cas9
(Silbering et al., 2016)
Progenitor genotype
Cytology
Description

10bp deletion in Ir40a is predicted to cause a translational frame-shift and premature translation termination.

(Silbering et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:22,196,390..22,196,399 [-]
Comment:

10 bp deletion in Ir40a coding sequence leads to a frameshfit.

(Silbering et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ir40a1 mutant adults have a loss of the increase in heat avoidance displayed by controls when heat is coupled with dry conditions, relative to humid conditions; they also have a significantly reduced avoidance of dry conditions at optimal temperature, but no difference in temperature preferences compared to controls.

      (Frank et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      IR40a1
      (Frank et al., 2017, Silbering et al., 2016)
      Ir40a mutant
      (Lee et al., 2025)
      Ir40a1
      (Knecht et al., 2017, Knecht et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)