FB2026_02 , released June 18, 2026
Allele: Dmel\axedCrisprA
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General Information
Symbol
Dmel\axedCrisprA
Species
D. melanogaster
Name
FlyBase ID
FBal0327538
Feature type
allele
Associated gene
Dmel\axed
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Neukomm et al., 2017)
Progenitor genotype
Cytology
Description

194bp deletion in exon 2 of axed.

(Neukomm et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:6,616,188..6,616,381 [+]
Comment:

axedCrisprA contains a 194 bp deletion in the axed coding region as well as three downstream mutations, the addition of a G between 3L:6616386 and 3L:6616387 , the deletion of G at 3L:6616390 and an A to C missense mutation at 3L:6616391 .

(Neukomm et al., 2018.1.29)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying axedCrisprA mutant somatic clones show defective injury-induced axon degeneration: severed axons in sensory neurons in the adult wing remain intact for a full week after an axotomy, instead of being cleared away.

      (Neukomm et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      axed0011

      (Neukomm et al., 2017)

      axed2094

      (Neukomm et al., 2017)
      Comments

      axedCrisprA fails to complement the lethality of either axed0011 or axed2094 mutants.

      (Neukomm et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AxedCrispA
      (Neukomm et al., 2018.1.29)
      axedCrisprA
      (Neukomm et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)