FB2026_02 , released June 18, 2026
Allele: Dmel\axedΔCterm.UAS
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General Information
Symbol
Dmel\axedΔCterm.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0327549
Feature type
allele
Associated gene
Dmel\axed
Associated Insertion(s)
Carried in Construct
P{UAS-axed.ΔCterm}
Key Links
Transgenic product class
inframe_deletion
(Neukomm et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Neukomm et al., 2017)
Mutagen
in vitro construct
(Neukomm et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-axed.ΔCterm}
Cytology
Description

UAS regulatory sequences drive expression of axed cDNA (the long isoform) with deletion (aa442-537) of the C-terminal.

(Neukomm et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
axed
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      axedΔCterm.UAS/Scer\GAL4VGlut1-OK371 fails to rescue axed0011

      (Neukomm et al., 2017)

      axedΔCterm.UAS/Scer\GAL4VGlut1-OK371 fails to rescue axed2094

      (Neukomm et al., 2017)

      axedΔCterm.UAS/Scer\GAL4VGlut1-OK371 fails to rescue axedMI13270

      (Neukomm et al., 2017)
      Comments

      The defective injury-induced axon degeneration observed in flies carrying axed0011, axed2094 or axedMI13270 mutant neural clones (severed axons in sensory neurons in the adult wing remain intact following an axotomy, instead of being cleared away) can be rescued by clonal Scer\GAL4VGlut-OK371-driven expression of axedΔCterm.Scer\UAS.

      (Neukomm et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      axedΔCterm.Scer\UAS
      axedΔCterm.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)