FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\palRT4
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General Information
Symbol
Dmel\palRT4
Species
D. melanogaster
Name
FlyBase ID
FBal0336425
Feature type
allele
Associated gene
Dmel\pal
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Kondo et al., 2017)
Progenitor genotype
Cytology
Description

Indel near the beginning of the coding sequence that results in a frameshift (and is predicted to result in a premature stop codon - see FBrf0236926). The indel also creates three potential start codons in frame with the rest of the wild-type pal coding sequence, and thus it is possible that these could generate three potential proteins containing the last 87 amino acids of the wild-type pal protein. Complementation data (palRT4 complements pal1) indicates that pal function is not affected in this mutant.

(Dubruille et al., 2023)

A frameshift allele that truncates the majority of the coding potential of the gene.

(Kondo et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2L:9,625,127..9,625,130 [-]
Inserted_sequence:

ATTCA

Comment:

The deletion of 4 bp and insertion of 5 bp resulting in a net insertion of 1base in the CG31882 coding region.

Comment:

FBrf0258075 reports a G to C nucleotide change three bases downstream from the previously reported delins (CAATT replaced with ATTCA).

(Dubruille et al., 2023, Kondo et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CG31882RT4 mutant adults do not show any overt morphological defects.

      (Kondo et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG31882RT4
      (Dubruille et al., 2023)
      palRT4
      (Dubruille et al., 2023)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)