FlyBase Allele Report: Dmel\MetRS-m[ninaE.KK108492]

General Information

Symbol

Dmel\MetRS-m^{ninaE.KK108492}

Species

D. melanogaster

Name

FlyBase ID

FBal0336592

Feature type

allele

Associated gene

Dmel\MetRS-m

Associated Insertion(s)

Carried in Construct

P{ninaE-MetRS-m-KK108492}

Key Links

Transgenic product class

RNAi_reagent

(Liu et al., 2017)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Liu et al., 2017)

Mutagen

in vitro construct

(Liu et al., 2017)

Progenitor genotype

Carried in construct

P{ninaE-MetRS-m-KK108492}

Cytology

Description

A ninaE promoter drives expression of dsRNA-KK108492.

(Liu et al., 2017)

Allele components

Component

Use(s)

Regulatory region(s)

ninaE

Encoded product / tool

dsRNA-KK108492

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult optic lobe glial cell | cell non-autonomous

(Liu et al., 2017)

lipid droplet | adult stage | cell non-autonomous

(Liu et al., 2017)

Detailed Description

Statement

Reference

Expression of MetRS-m^{ninaE.KK108492} in photoreceptors induces formation of lipid droplets in the neighboring glial cells.

(Liu et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

MetRS-m^{ninaE.KK108492} has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible | partially by Pdha1^A/Pdha[+]

(Liu et al., 2017)

MetRS-m^{ninaE.KK108492} has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible | partially by Pdha1^A/Pdha[+]

(Liu et al., 2017)

MetRS-m^{ninaE.KK108492} has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible | partially by kdn[+]/Cs1^A

(Liu et al., 2017)

MetRS-m^{ninaE.KK108492} has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible | partially by kdn[+]/Cs1^A

(Liu et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The accumulation of lipid droplets in glial cells in the vicinity of adult photoreceptor neurons expressing ND-42^ninaE.GD6220 is

(Liu et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

80146

w^*; P{ninaE-MetRS-m-KK108492}3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

MetRS-m^{ninaE.KK108492}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close