FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\zdanull
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General Information
Symbol
Dmel\zdanull
Species
D. melanogaster
Name
FlyBase ID
FBal0336667
Feature type
allele
Associated gene
Dmel\zda
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Melani et al., 2017)
Mutagen
P-element activity
(Melani et al., 2017)
Progenitor genotype
P{EPgy2}zdaEY08359
(Melani et al., 2017)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in removal of 1100 base pairs of the zda coding region, including the transcription initiation site.

(Melani et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      zdanull homozygotes die at first larval molt.

      Mosaic third instar larvae carrying randomly induced zdanull clones fail to accumulate LysoTracker (a marker of autophagy) in mutant cells in either the fat body or wing discs upon starvation.

      (Melani et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      zdanull is rescued by zdaUAS.mCherry/Scer\GAL4ppl.PP

      (Melani et al., 2017)
      Comments

      Scer\GAL4ppl.PP-driven expression of zdaUAS.mCherry rescues zdanull homozygotes to viability.

      (Melani et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      zdanull
      (de la Riva-Carrasco et al., 2021, Melani et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)