Prosap749 homozygotes are fully viable and fertile, without apparent morphological or developmental abnormalities, but adults present significant decreases in locomotor capacity, in olfactory acuity and in olfactory learning, but normal avoidance behavior upon electric shock stimuli, as compared to controls.
The adult mushroom body calyx glomeruli of Prosap749 homozygotes present a severe decrease in the number of presynaptic bouton protrusions, as compared to controls.
The larval neuromuscular junctions of Prosap749 homozygotes display no significant changes in spontaneous excitatory junctional potential frequency or amplitude, or in evoked excitatory junctional potential amplitude, at 0.4 or 1.0 mM Ca[2+] concentrations, as compared to controls.
