FB2026_02 , released June 18, 2026
Allele: Dmel\Prosap138
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General Information
Symbol
Dmel\Prosap138
Species
D. melanogaster
Name
FlyBase ID
FBal0336719
Feature type
allele
Associated gene
Dmel\Prosap
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Wu et al., 2017)
Mutagen
CRISPR/Cas9
(Wu et al., 2017)
Progenitor genotype
Cytology
Description

A 28 bp DNA deletion in exon 5 at amino acid 138 of the longest Prosap coding starting region, resulting in a frameshift at the N-terminus that affects all known Prosap isoforms.

(Wu et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Prosap138 homozygotes are fully viable and fertile, without apparent morphological or developmental abnormalities. The adult mushroom body calyx glomeruli of these mutants present a severe decrease in the number of presynaptic bouton protrusions, as compared to controls.

      (Wu et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Prosap138
      Shank138
      (Wu et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)