UAS regulatory sequences drive expression of wor cDNA (codon optimized for Drosophila, omitting endogenous 5' and 3' UTR) with replacement of the N-terminal with the VP16 activation domain. Tagged with Tag:FLAG at the C-terminal.
Comments on Models/Modifiers Based on Experimental Evidence
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Disease-implicated variant(s)
Phenotypic Data
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The T1 and T2 segments of stage 16 embryos expressing worVP16.UAS.Tag:FLAG under the control of Scer\GAL4elav-C155 do not show significant changes in the numbers of dividing neuroblasts and dividing neuroblast daughters, as compared to controls.