FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\aseVP16.UAS.Tag:MYC
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General Information
Symbol
Dmel\aseVP16.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0337786
Feature type
allele
Associated gene
Dmel\ase
Associated Insertion(s)
Carried in Construct
PBac{UAS-ase.VP16.MYC}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Bahrampour et al., 2017)
Progenitor genotype
Carried in construct
PBac{UAS-ase.VP16.MYC}
Cytology
Description

UAS regulatory sequences drive expression of ase cDNA (codon optimized for Drosophila, omitting endogenous 5' and 3' UTR) with replacement of the C-terminal with the VP16 activation domain. Tagged with Tag:MYC.

(Bahrampour et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
ase
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The T1 and T2 segments of stage 16 embryos expressing aseEnR.UAS.Tag:MYC under the control of Scer\GAL4elav-C155, but not Scer\GAL4lbe.K, show significant increases in the numbers of dividing neuroblasts and dividing neuroblast daughters, as compared to controls; stage 17 (air-filled trachea) embryos also show increased neuroblast division compared to controls.

      (Bahrampour et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      At stage 11 combinatorial expression of aseVP16.UAS.Tag:MYC, worEnR.UAS.Tag:FLAG, SoxNEnR.UAS.Tag:V5 and KrUAS.Tag:V5 under the control of Scer\GAL4da.G32 leads to extensive ectopic neuroblasts not only in the underlying cell layers, but also in the upper neuroectodermal layer when compared to control embryos.

      (Arefin et al., 2019)

      The triple co-expression of aseVP16.UAS.Tag:MYC, worEnR.UAS.Tag:FLAG and SoxNEnR.UAS.Tag:V5, or quadruple co-expression with KrUAS.Tag:V5, under the control of Scer\GAL4da.G32 triggers additional neuroblast and extensive over-proliferation in stage 12 embryos, as compared to controls. Quadruple expression under the control of Scer\GAL4lbe.K leads to the expansion of the NB5-6 neuronal lineage in late embryos, as compared to controls.

      (Bahrampour et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      aseScer\UAS.T:Hsim\VP16,T:Hsap\MYC
      aseVP16.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)