FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rh70
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General Information
Symbol
Dmel\Rh70
Species
D. melanogaster
Name
FlyBase ID
FBal0338112
Feature type
allele
Associated gene
Dmel\Rh7
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Kistenpfennig et al., 2017)
Mutagen
Delta2-3 transposase
(Kistenpfennig et al., 2017)
Progenitor genotype
P{EPgy2}EY13118
(Kistenpfennig et al., 2017)
Cytology
Description

Imprecise excision of P{EPgy2}EY13118 results in a 10.35kb deletion in Rh7.

(Kistenpfennig et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:12,165,278..12,175,628 [-]
Comment:

Estimated breakpoints of a ~10.35 kb deletion resulting from the imprecise excision of P{EPgy2}EY13118 thar removes the Rh7 coding region.

(Kistenpfennig et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rh70 homozygous adults reared under 12h:12h white light:dark cycles exhibit a significantly earlier morning activity onset and a significantly longer siesta, but insignificant changes in the evening activity onset, as compared to controls. These mutants show a significant delay in resynchronization to a 6h delay or advance in 12h:12h 470nm light:dark cycle, but not white light or 400nm light:dark cycles, as compared to controls. These mutants become arrhythmic after a few days of constant light, but not constant darkness, as compared to controls.

      (Kistenpfennig et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Rh70 has abnormal locomotor rhythm | adult stage phenotype, enhanceable by cry01/cry01

      (Kistenpfennig et al., 2017)
      NOT Enhanced by
      Statement
      Reference

      Rh70, norpAP41 has abnormal circadian behavior | adult stage phenotype, non-enhanceable by cry01/cry01

      (Kistenpfennig et al., 2017)
      Enhancer of
      Statement
      Reference

      Rh70/Rh70 is an enhancer of abnormal locomotor rhythm | adult stage phenotype of cry01

      (Kistenpfennig et al., 2017)
      NOT Enhancer of
      Statement
      Reference

      Rh70/Rh70 is a non-enhancer of abnormal circadian behavior | adult stage phenotype of cry01, norpAP41

      (Kistenpfennig et al., 2017)
      Suppressor of
      Statement
      Reference

      Rh70/Rh70 is a suppressor of abnormal locomotor rhythm | adult stage phenotype of cry01

      (Kistenpfennig et al., 2017)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Rh70, cry01 double-homozygous adults exhibit: an earlier morning activity onset as compared to controls, which is more severe than both single mutant; an earlier evening activity onset as compared to controls, instead of the later evening activity onset observed in cry01 mutants; and a longer siesta as compared to controls, which is slightly shorter than that of cry01 mutants. These double mutants do not show any obvious rhythmicity defects after a few days of either constant light or darkness, as compared to controls.

      Rh70, norpA39 and cry01, norpA39 double-homozygous adults reared under 12h:12h white light:dark cycles exhibit a significant delay in resynchronizing to a 6h delay in 12h:12h white light:dark cycle compared to controls; these phenotypes are not enhanced by additional cry01 and Rh70 homozygosity, respectively.

      (Kistenpfennig et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Rh70
      (Kistenpfennig et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)