FB2026_02 , released June 18, 2026
Allele: Dmel\unc-13EMS7.96
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General Information
Symbol
Dmel\unc-13EMS7.96
Species
D. melanogaster
Name
FlyBase ID
FBal0338123
Feature type
allele
Associated gene
Dmel\unc-13
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Böhme et al., 2016)
Mutagen
ethyl methanesulfonate
(Böhme et al., 2016)
Progenitor genotype
Cytology
Description

8bp deletion resulting in a premature stop codon that specifically affects translation of the A protein isoform.

(Böhme et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
4:898,513..898,521 [-]
Comment:

A 9bp deletion (AAAAAAACG) and one base insertion (T) causes a frameshift resulting in premature translation termination. The mutation is isoform-specific, affecting isoforms unc-13-PA, unc-13-PC, unc-13-PD, unc-13-PF, and unc-13-PG.

Inserted_sequence:

T

(Böhme et al., 2018.6.13)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      unc-13EMS7.96/unc-13P84200 transheterozygotes are nearly lethal, as they give rise to few larvae, which hardly move and only occasionally develop into weak adult flies.

      (Böhme et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      unc-13EMS7.96/unc-13P84200 is rescued by unc-13+tBa

      (Böhme et al., 2016)
      Comments

      The near lethality of unc-13EMS7.96/unc-13P84200 transheterozygotes is rescued by unc-13+tBa.

      (Böhme et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      7.96
      (Böhme et al., 2018.6.13)
      EMS7.96
      (Böhme et al., 2016)
      unc-13EMS7.96
      Name Synonyms
      Secondary FlyBase IDs
        References (2)