FB2026_02 , released June 18, 2026
Allele: Dmel\Nulp13
Open Close
General Information
Symbol
Dmel\Nulp13
Species
D. melanogaster
Name
FlyBase ID
FBal0340357
Feature type
allele
Associated gene
Dmel\Nulp1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Zeng et al., 2018)
Progenitor genotype
Cytology
Description

A 1bp insertion at the 1011bp locus in the third exon (CDS) of Nulp1, resulting in a premature stop codon within the DUF654 domain, producing an abbreviated poly-peptide chain after 375 amino acids.

(Zeng et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
insertion
3L:8,111,654..8,111,655 [+]
Inserted_sequence:

G

Comment:

The insertion of a "G" base between the indicated bases in the third exon of Nulp1 causes a frameshift and early translation termination.

(Zeng et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Nulp13 homozygotes are semi-lethal, with the 80% of individuals dying during the pupal stage; the escapers exhibit fully penetrant bent femurs.

      (Zeng et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Nulp13
      dNulp13#
      (Zeng et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)