FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Megf8Δ1
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General Information
Symbol
Dmel\Megf8Δ1
Species
D. melanogaster
Name
FlyBase ID
FBal0340377
Feature type
allele
Associated gene
Dmel\Megf8
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Lloyd et al., 2018)
Mutagen
CRISPR/Cas9
(Lloyd et al., 2018)
Progenitor genotype
Cytology
Description

Deletion of 1 bp within exon 1 of Megf8, resulting in a frameshift and early termination of the coding sequence.

(Lloyd et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:8,043,740..8,043,740 [+]
Comment:

A one bp deletion in the first exon of Megf8 leads to a frameshift after the eighth amino acid and early translation termination.

(Lloyd et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Megf8Δ1 homozygous and Megf8Δ1/Megf8Δ8 transheterozygous larvae show a severe developmental delay in the L2-L3 transition and display an abnormal feeding behavior, leaving the food as early as larval day two, as compared to controls; these mutant larvae have planar polarity defects, as shown by the denticle belts organization, which range from a generally disorganized appearance to partially or completely missing belts or fused belts.

      (Lloyd et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Megf8Δ1
      dMegf8Δ1
      (Lloyd et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)