FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\nAChRα1KO
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General Information
Symbol
Dmel\nAChRα1KO
Species
D. melanogaster
Name
FlyBase ID
FBal0341667
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Dα1KO
Key Links
Genomic Maps

Nature of the Allele
Progenitor genotype
Associated Insertion(s)
Cytology
Description

57kb deletion that removes the nAChRα1 transcription unit. A single attP site and a single loxP site are inserted in place of the deleted sequence.

Allele components
Component
Use(s)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Comment:

A 57.1kb deletion of nAChRalpha1 was created by ends-out targeting. Deletion endpoints determined from reported sequences.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

nAChRα1KO mutant males consistently take longer to initiate both courtship and copulation compared to wild-type males, regardless of the genotype of the female partner (mutant or wild-type); mutant females also take longer to initiate copulation with wild-type males compared to wild-type females. nAChRα1KO mutant adults show a decrease in sleep time and are hyperactive despite a lower average speed, as compared to controls; mutants show a decrease in locomotor speed during the 3-12h period (day-time) and a converse increase in activity during the 15-24h period (night-time), as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)