FlyBase Allele Report: Hsap\PINK1[ΔMTS.UAS.Tag:FLAG]

General Information

Symbol

Hsap\PINK1^{ΔMTS.UAS.Tag:FLAG}

Species

H. sapiens

Name

FlyBase ID

FBal0341848

Feature type

allele

Associated gene

Hsap\PINK1

Associated Insertion(s)

Carried in Construct

P{UAS-hPINK1.ΔMTS.FLAG}

Key Links

Transgenic product class

inframe_deletion

(Tsai et al., 2018)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Tsai et al., 2018)

Mutagen

in vitro construct

(Tsai et al., 2018)

Progenitor genotype

Carried in construct

P{UAS-hPINK1.ΔMTS.FLAG}

Cytology

Description

UASt regulatory sequences drive expression of a fragment encoding AAs 112-581 of Hsap\PINK1 (without the mitochondrial targeting sequence), tagged at the C-terminal with Tag:FLAG.

(Tsai et al., 2018)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\PINK1

Tagged with

Tag:FLAG

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Pink1^B9

(Tsai et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Hsap\PINK1^{ΔMTS.UAS.Tag:FLAG} is a suppressor of decreased cell number | adult stage phenotype of Pink1^B9

(Tsai et al., 2018)

NOT Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Hsap\PINK1^{ΔMTS.UAS.Tag:FLAG} is a non-suppressor of abnormal locomotor behavior phenotype of Pink1^B9

(Tsai et al., 2018)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Hsap\PINK1^{ΔMTS.UAS.Tag:FLAG} is a suppressor of dopaminergic PPL1 neuron | adult stage phenotype of Pink1^B9

(Tsai et al., 2018)

NOT Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Hsap\PINK1^{ΔMTS.UAS.Tag:FLAG} is a non-suppressor of mitochondrion | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Hsap\PINK1^{ΔMTS.UAS.Tag:FLAG} is a non-suppressor of mitochondrial crista | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Hsap\PINK1^{ΔMTS.UAS.Tag:FLAG} is a non-suppressor of mitochondrial crista junction | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Hsap\PINK1^{ΔMTS.UAS.Tag:FLAG} is a non-suppressor of embryonic/larval hypodermal muscle cell | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Hsap\PINK1^{ΔMTS.UAS.Tag:FLAG} is a non-suppressor of mitochondrion | adult stage phenotype of Pink1^B9

(Tsai et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsap\PINK1^{ΔMTS.UAS.Tag:FLAG}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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