FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Aplnull1
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General Information
Symbol
Dmel\Aplnull1
Species
D. melanogaster
Name
FlyBase ID
FBal0342113
Feature type
allele
Associated gene
Dmel\Apl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(VanKuren and Long, 2018)
Mutagen
CRISPR/Cas9
(VanKuren and Long, 2018)
Progenitor genotype
Cytology
Description

Deletion within Apl (does not encompass the transcription start site).

(VanKuren and Long, 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:16,595,430..16,595,619 [+]
Comment:

190 bp deletion that removes the ATG and most of the first coding exon.

(VanKuren and Long, 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Aplnull1 homozygous females produce significantly more offspring than controls.

      Aplnull1 homozygous males produce no mature sperm, as spermatids fail to individualize; in agreement, no sperm is observed in the seminal vesicle.

      (VanKuren and Long, 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Aplnull1 is partially rescued by Apl+RC

      (VanKuren and Long, 2018)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Aplnull1
      (VanKuren and Long, 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)