FB2026_02 , released June 18, 2026
Allele: Dmel\shopC15
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General Information
Symbol
Dmel\shopC15
Species
D. melanogaster
Name
FlyBase ID
FBal0342157
Feature type
allele
Associated gene
Dmel\shop
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Otto et al., 2018)
Mutagen
CRISPR/Cas9
(Otto et al., 2018)
Progenitor genotype
Cytology
Description

A deletion of 7 nucleotides at position 39 of shop leading to premature termination of translation after 25 amino acids.

(Otto et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:18,848,244..18,848,250 [-]
Comment:

A deletion of 7 nucleotides beginning at position 39 relative to the AUG of shop that leads to a frameshift at amno acid 13 and premature translation termination after the addition of 12 novel amino acids.

(Otto et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  isolated sulfite oxidase deficiency
      CEA
      (Martelli et al., 2024)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      shopC15 mutant third instar larvae show impaired crawling, namely a severe increase in head bending during crawling, but show no obvious mitochondria abnormalities in the brain, as compared to controls.

      shopC15 maternal zygotic mutants (from shopC15 homozygous mothers and shopC15 hemizygous fathers rescued for sterility by Dp(1;3)DC353) die during late embryogenesis without any noticeable morphological defects.

      (Otto et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      shopC15 is rescued by shopUAS.Tag:HA

      (Otto et al., 2018)
      Comments

      The expression of shopUAS.Tag:HA (in the absence of a GAL4 driver) rescues the male sterility of shopC15 hemizygotes.

      (Otto et al., 2018)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      shopC15
      (Mele et al., 2026, Martelli et al., 2024, Otto et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)