FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SIFa2
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General Information
Symbol
Dmel\SIFa2
Species
D. melanogaster
Name
FlyBase ID
FBal0343274
Feature type
allele
Associated gene
Dmel\SIFa
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Bai et al., 2018)
Progenitor genotype
Cytology
Description

Deletion covering both exons of SIFa ( 2R:24577763-24578080 ).

(Bai et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:24,577,763..24,578,080 [-]
Comment:

A 318bp deletion that removes both exons of SIFa maps to 2R:24577763-24578080 .

(Bai et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  tauopathy
      CEA
      (Bai et al., 2018)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      SIFa2 homozygotes and SIFa2/SIFa3 transheterozygotes show a significant decrease in sleep time, as compared to heterozygous and wild-type controls.

      SIFa2/Df(2R)BSC780 transheterozygotes and SIFa2 homozygotes are mostly circadian rhythmic, although with a lower rhythmic strength, as compared to heterozygous and wild-type controls.

      (Bai et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      SIFa3/SIFa2 has abnormal sleep phenotype, enhanceable by Nf1P2/Nf1P1

      (Bai et al., 2018)
      NOT Enhancer of
      Statement
      Reference

      SIFa[+]/SIFa2 is a non-enhancer of abnormal sleep phenotype of Nf1P2/Nf1P1

      (Bai et al., 2018)

      SIFa3/SIFa2 is a non-enhancer of abnormal sleep phenotype of Nf1P2/Nf1P1

      (Bai et al., 2018)
      NOT Suppressor of
      Statement
      Reference

      SIFa[+]/SIFa2 is a non-suppressor of abnormal sleep phenotype of Nf1P2/Nf1P1

      (Bai et al., 2018)

      SIFa3/SIFa2 is a non-suppressor of abnormal sleep phenotype of Nf1P2/Nf1P1

      (Bai et al., 2018)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      SIFa2
      (Song et al., 2025, Dreyer et al., 2019, Bai et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)