FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Atx2ΔmIDR
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General Information
Symbol
Dmel\Atx2ΔmIDR
Species
D. melanogaster
Name
FlyBase ID
FBal0343430
Feature type
allele
Associated gene
Dmel\Atx2
Associated Insertion(s)
Carried in Construct
PBac{Atx2.ΔmIDR}
Key Links
Transgenic product class
inframe_deletion
(Bakthavachalu et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Bakthavachalu et al., 2018)
Mutagen
in vitro construct
(Bakthavachalu et al., 2018)
Progenitor genotype
Carried in construct
PBac{Atx2.ΔmIDR}
Cytology
Description

Genomic fragment containing the Atx2 locus. Sequence encoding Atx2 amino acid residues 420-440 (prion-like domain) and 548-656 (endogenous polyQ repeats) have been deleted. The deleted sequence comprises the internal intrinsically disordered region.

(Bakthavachalu et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
Atx2
Encoded product / tool
Atx2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult Atx2X1/Atx206490 transheterozygotes bearing Atx2ΔmIDR exhibit significantly lower long-term olfactory habituation, as compared to controls.

      (Bakthavachalu et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Atx2ΔmIDR rescues Atx2X1

      (Bakthavachalu et al., 2018)

      Atx2ΔmIDR rescues Atx2X1/Atx206490

      (Bakthavachalu et al., 2018)
      Comments

      Atx2ΔmIDR rescues the lethality of Atx2X1/Atx206490 and the dendrite targeting defects of Atx2X1 adult antennal lobe projection neuron clones.

      (Bakthavachalu et al., 2018)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Atx2ΔmIDR
      Name Synonyms
      Secondary FlyBase IDs
        References (1)