FB2026_02 , released June 18, 2026
Allele: Dmel\ohgtex1
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General Information
Symbol
Dmel\ohgtex1
Species
D. melanogaster
Name
FlyBase ID
FBal0343555
Feature type
allele
Associated gene
Dmel\ohgt
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Choi et al., 2018)
Mutagen
P-element activity
(Choi et al., 2018)
Progenitor genotype
P{GSV6}GS14825
(Choi et al., 2018)
Cytology
Description

1160bp deletion that removes part of the ohgt gene, including the transcription start site. Generated by imprecise excision of P{GSV6}GS14825.

(Choi et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      The disease model uses ohgt[ex1] in combination with a deficiency encompassing the locus. FlyBase curator comment: ohgt is the ortholog of human CRBN, which is associated with MIM:607417.

      (Choi et al., 2018)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The larval neuromuscular junctions of ohgtex1/Df(3R)BSC621 transheterozygotes exhibit a significant increase in paired-pulsed ratio and altered short-term plasticity (i.e. increased excitatory junctional current amplitudes in high frequency pulse train stimulation) but show normal miniature excitatory junctional current amplitude and frequency and normal evoked excitatory junctional current amplitude, as compared to controls. These neuromuscular junctions show an apparently normal synaptic structure/number of boutons, as compared to controls.

      The larval neuromuscular junctions of ohgtex1/Df(3R)BSC621 transheterozygotes that also express ohgtG552X.UAS.Tag:MYC under the control of Scer\GAL4elav-C155 show significantly decreased miniature excitatory junctional current frequencies, which are not observed either in ohgtex1/Df(3R)BSC621 transheterozygotes or in wild-type controls.

      (Choi et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CRBNex1
      (Choi et al., 2018)
      ohgtex1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)