FB2026_02 , released June 18, 2026
Allele: Dmel\ohgtG552X.UAS.Tag:MYC
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General Information
Symbol
Dmel\ohgtG552X.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0343557
Feature type
allele
Associated gene
Dmel\ohgt
Associated Insertion(s)
Carried in Construct
P{UAS-ohgt.G552X.Myc}
Key Links
Genomic Maps

Transgenic product class
stop_gained
(Choi et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
stop_gained
(Choi et al., 2018)
Mutagen
in vitro construct
(Choi et al., 2018)
Progenitor genotype
Carried in construct
P{UAS-ohgt.G552X.Myc}
Cytology
Description

UASt regulatory sequences drive expression of the ohgt LD28592 cDNA which has been mutated to carry a premature stop codon at residue 552 (this mimics the human CRBN R419X pathogenic mutant). The open reading frame is tagged with Tag:MYC.

(Choi et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ohgt
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:10,051,217..10,051,219 [+]
Nucleotide change:

GGC10051217TGA

Amino acid change:

G552term | ohgt-PA

Reported amino acid change:

G552X

Comment:

Analogous R419X mutation in human CRBN implicated in intellectual disability; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(Choi et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Choi et al., 2018)
      CRBN:p.Arg419Ter
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      CRBN:p.Arg418Ter
      Associated human disease model(s)
      External database links
      ClinVar: CRBN_1821
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The larval neuromuscular junctions of ohgtex1/Df(3R)BSC621 transheterozygotes that also express ohgtG552X.UAS.Tag:MYC under the control of Scer\GAL4elav-C155 show significantly decreased miniature excitatory junctional current frequencies, which are not observed either in ohgtex1/Df(3R)BSC621 transheterozygotes or in wild-type controls.

      (Choi et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ohgtG552X.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)