FlyBase Allele Report: Dmel\KCNQ[HMS06026]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\KCNQ^HMS06026

General Information

Symbol

Dmel\KCNQ^HMS06026

Species

D. melanogaster

Name

FlyBase ID

FBal0343735

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS06026}

Also Known As

UAS-KCNQ-RNAi

Key Links

Genomic Maps

Transgenic product class

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMS06026}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of developmental and epileptic encephalopathy 7

CEA

(Wang et al., 2024)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of developmental and epileptic encephalopathy 7

is ameliorated by Hsap\KCNQ2^{UAS.cBa.Tag:HA}

(Wang et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority live, with Scer\GAL4^elav.PU

(Wang et al., 2024)

short lived, with Scer\GAL4^elav.PU

(Wang et al., 2024)

some die during P-stage, with Scer\GAL4^elav.PU

(Wang et al., 2024)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

KCNQ^HMS06026, Scer\GAL4^elav.PU has short lived phenotype, suppressible by Hsap\KCNQ2^{UAS.cBa.Tag:HA}, Scer\GAL4^elav.PU

(Wang et al., 2024)

KCNQ^HMS06026, Scer\GAL4^elav.PU has increased mortality during development phenotype, suppressible by Hsap\KCNQ2^{UAS.cBa.Tag:HA}, Scer\GAL4^elav.PU

(Wang et al., 2024)

KCNQ^HMS06026, Scer\GAL4^elav.PU has some die during P-stage phenotype, suppressible by Hsap\KCNQ2^{UAS.cBa.Tag:HA}, Scer\GAL4^elav.PU

(Wang et al., 2024)

NOT suppressed by

Statement

Reference

KCNQ^HMS06026, Scer\GAL4^elav.PU has partially lethal - majority live phenotype, non-suppressible by Hsap\KCNQ2^{Ala336Glu.UAS}, Scer\GAL4^elav.PU

(Wang et al., 2024)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

80446

y¹ sc^* v¹ sev²¹; P{TRiP.HMS06026}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

KCNQ^HMS06026

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections