FB2026_02 , released June 18, 2026
Allele: Dmel\SAKRKA
Open Close
General Information
Symbol
Dmel\SAKRKA
Species
D. melanogaster
Name
FlyBase ID
FBal0343979
Feature type
allele
Associated gene
Dmel\SAK
Associated Insertion(s)
Carried in Construct
P{SAK.RKA}
Also Known As
Plk4RKA
Key Links
Transgenic product class
missense_variant
(Aydogan et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Aydogan et al., 2018)
Mutagen
in vitro construct
(Aydogan et al., 2018)
Progenitor genotype
Carried in construct
P{SAK.RKA}
Cytology
Description

SAK genomic fragment containing sequence from 2kb upstream of the predicted initiator methionine through to and including the stop codon. The coding sequence has been mutated to contain the L89G amino acid substitution, which reduces kinase activity.

(Aydogan et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
SAK
Encoded product / tool
SAK
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      SAKRKA/+ embryos exhibit a significant decrease in centriole size, a significantly reduced centriole growth rate but they do not exhibit any changes in centriole growth period, centriole duplication defects or changes in hatching rates when compared to controls.

      (Aydogan et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Plk4RKA
      (Aydogan et al., 2022, Aydogan et al., 2018)
      SAKRKA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)