FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PAPLA12
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General Information
Symbol
Dmel\PAPLA12
Species
D. melanogaster
Name
FlyBase ID
FBal0344003
Feature type
allele
Associated gene
Dmel\PAPLA1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Gáliková et al., 2017)
Mutagen
CRISPR/Cas9
(Gáliková et al., 2017)
Progenitor genotype
Cytology
Description

5978bp deletion (coordinates 2L:8140659..8134682 , release 6 genome) with a short ectopic sequence (CCATCCA) between the deletion breakpoints. This removes much of the PAPLA1 coding sequence.

(Gáliková et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2L:8,134,682..8,140,659 [-]
Comment:

A 5,978bp deletion that removes most of of the PAPLA1 coding sequence. A 7bp ectopic sequence (CCATCCA) is present at the site of the deletion. The deletion is reported to map to 2L:8134682..8140659 , R6 coordinates.

Inserted_sequence:

CCATCCA

(Gáliková et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  hereditary spastic paraplegia
      CEA
      (Gáliková et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PAPLA12 mutants are semi-lethal and show a delay to pupariation, but do not show differences in body size (assessed by pupal volume and wing size); adults show significant decreases in food intake an din spontaneous activity, as compared to controls. Mutant females mated to control males lay significantly fewer eggs, which hatch at slightly but significantly lower rate, as compared to control males. Mating between mutant males and control females leads to decreased egg laying and decreased egg hatch rate, as compared to control males.

      (Gáliková et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      PAPLA12
      (Gáliková et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)