FlyBase Allele Report: Dmel\Pex2[2]

General Information

Symbol

Dmel\Pex2²

Species

D. melanogaster

Name

FlyBase ID

FBal0344182

Feature type

allele

Associated gene

Dmel\Pex2

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Wangler et al., 2017)

Progenitor genotype

P{EPg}Pex2^HP35039

(Wangler et al., 2017)

Cytology

Description

11bp insertion within a 473bp deletion.

(Gomez et al., 2025)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of peroxisome biogenesis disorder 5A

CEA

(Wangler et al., 2017)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage (with Df(3L)BSC376)

(Wangler et al., 2017)

abnormal locomotor behavior | adult stage | nutrition conditional (with Df(3L)BSC376)

(Wangler et al., 2017)

abnormal neuroanatomy | adult stage (with Pex2^{CR70193-KO-kG4})

(Gomez et al., 2025)

abnormal neurophysiology | adult stage (with Df(3L)BSC376)

(Wangler et al., 2017)

abnormal size | adult stage (with Pex2^{CR70193-KO-kG4})

(Gomez et al., 2025)

abnormal starvation stress response | adult stage (with Df(3L)BSC376)

(Wangler et al., 2017)

bang sensitive (with Df(3L)BSC376)

(Wangler et al., 2017)

bang sensitive | progressive (with Pex2^{CR70193-KO-kG4})

(Gomez et al., 2025)

decreased rate of adult locomotory behavior | progressive (with Pex2^{CR70193-KO-kG4})

(Gomez et al., 2025)

flightless (with Df(3L)BSC376)

(Wangler et al., 2017)

partially lethal (with Pex2^{CR70193-KO-kG4})

(Gomez et al., 2025)

short lived (with Df(3L)BSC376)

(Wangler et al., 2017)

short lived (with Pex2^{CR70193-KO-kG4})

(Gomez et al., 2025)

short lived | nutrition conditional (with Df(3L)BSC376)

(Wangler et al., 2017)

Phenotype Manifest In

adult motor neuron (with Pex2^{CR70193-KO-kG4})

(Gomez et al., 2025)

axon | adult stage (with Pex2^{CR70193-KO-kG4})

(Gomez et al., 2025)

embryonic/larval salivary gland | larval stage (with Df(3L)BSC376)

(Wangler et al., 2017)

peroxisome | larval stage (with Df(3L)BSC376)

(Wangler et al., 2017)

retina | adult stage (with Df(3L)BSC376)

(Wangler et al., 2017)

Detailed Description

Statement

Reference

Pex2²/Df(3L)BSC376 transheterozygotes show peroxisome biogenesis defects in larval salivary glands, as indicated by the severely decreased Pex3 punctate staining.

Pex2²/Df(3L)BSC376 transheterozygous adults show severely reduced activity and decreased electroretinogram amplitude under standard diet, as compared to controls. These mutants survive for less time and show increased activity under either complete starvation or low-sugar diet, as compared to controls.

(Wangler et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Pex2²/Pex2^{CR70193-KO-kG4} has decreased rate of adult locomotory behavior | progressive phenotype, non-enhanceable by Hsap\PEX2^{C247R.UAS.GFP}

(Gomez et al., 2025)

Pex2²/Pex2^{CR70193-KO-kG4} has decreased rate of adult locomotory behavior | progressive phenotype, non-enhanceable by Hsap\PEX2^{W223term.UAS.GFP}