FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Vha68-11
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General Information
Symbol
Dmel\Vha68-11
Species
D. melanogaster
Name
FlyBase ID
FBal0344219
Feature type
allele
Associated gene
Dmel\Vha68-1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Zhao et al., 2018)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q519L.

(Zhao et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:13,001,756..13,001,756 [-]
Nucleotide change:

A13001756T

Amino acid change:

Q519L | Vha68-1-PA; Q519L | Vha68-1-PB

Reported amino acid change:

Q519L

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Zhao et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Alzheimer's disease 1
      modeled by Hsap\APPAβ42.UAS.Tag:SS(rPENK)
      (Wang et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Vha68-11 homozygous whole-eye clones, induced in the third instar larva, lose on-off retinal transients in response to short light pulses and have a significant reduction in light sensitivity in the adult compared to controls; photoreceptor cells also have anterograde (ninaE and trp localization), but not retrograde (Atpα localization), transport defects and there is an increase in number of secretory vesicles compared to controls. These clones lose photoreceptor cells and rhabdomeres over time in a light-independent manner.

      (Zhao et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Enhancer of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Vha68-2ninaE.PZ or Vha68-3ninaE.PZ completely rescues loss and vesicle-accumulation phenotypes of Vha68-11/Vha68-11 photoreceptor cells.

      (Zhao et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Vha68-11 is rescued by Vha68-1Ubi.PZ

      (Zhao et al., 2018)

      Vha68-11 is rescued by Vha68-1ninaE.PZ

      (Zhao et al., 2018)
      Comments

      Vha68-1ninaE.PZ completely rescues loss and vesicle-accumulation phenotypes of Vha68-11/Vha68-11 photoreceptor cells. Vha68-1Ubi.PZ completely restores on-off retinal transients in Vha68-11/Vha68-11 whole-eye clones.

      (Zhao et al., 2018)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Vha68-11
      (Wang et al., 2021)
      vha68-11
      (Zhao et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)