FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\TREM2R47H.13xlexAop.Tag:MYC,Tag:FLAG
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General Information
Symbol
Hsap\TREM2R47H.13xlexAop.Tag:MYC,Tag:FLAG
Species
H. sapiens
Name
FlyBase ID
FBal0345086
Feature type
allele
Associated gene
Hsap\TREM2
Associated Insertion(s)
Carried in Construct
P{lexAop2-hTREM2.R47H}
Key Links
Transgenic product class
missense_variant
(Sekiya et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Sekiya et al., 2018)
Mutagen
in vitro construct
(Sekiya et al., 2018)
Progenitor genotype
Carried in construct
P{lexAop2-hTREM2.R47H}
Cytology
Description

13XLexAop2 regulates expression of a cDNA encoding the full length of Hsap\TREM2 (NM_018965, RC221132) containing the Alzheimer's disease-associated R47H variant, with a Tag:MYC-DDK (Tag:FLAG) tag.

(Sekiya et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
lexAop
Encoded product / tool
Hsap\TREM2
Tagged with
Tag:FLAG
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Alzheimer's disease
      modeled by Hsap\APPAβ42.UAS.Tag:SS(rPENK)
      (Sekiya et al., 2018)
      modeled by Hsap\MAPTUAS.cSa
      (Sekiya et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 2 )
       

      Co-expression of Hsap\TREM2R47H.13xlexAop.Tag:MYC,Tag:FLAG and Hsap\TYROBP13xlexAop.Tag:MYC,Tag:FLAG in glia exacerbates exacerbates some effects of neuronal Hsap\APPAβ42.UAS.Tag:SS(rPENK) expression.

      (Sekiya et al., 2018)

      Co-expression of Hsap\TREM2R47H.13xlexAop.Tag:MYC,Tag:FLAG and Hsap\TYROBP13xlexAop.Tag:MYC,Tag:FLAG in glia exacerbates progressive neurodegeneration caused by Hsap\MAPTUAS.cSa expression in photoreceptor neurons.

      (Sekiya et al., 2018)
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Sekiya et al., 2018)

      Direct disease model in flies has not been developed; genetic interactions in context of a disease model have been assessed.

      TREM2:p.Arg47His
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
        External database links
        ClinVar: TREM2_195350
        Comments concerning this variant
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference

        The co-expression of Hsap\TYROBP13xlexAop.Tag:MYC,Tag:FLAG and Hsap\TREM2R47H.13xlexAop.Tag:MYC,Tag:FLAG under the control of Ecol\lexAGAD.repo does not result in significant changes in the size or gross morphology of adult brain structures, nor in the numbers of glial cells or neurons, as compared to controls.

        (Sekiya et al., 2018)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Hsap\TREM2R47H.13xlexAop.Tag:MYC,Tag:FLAG
        Name Synonyms
        Secondary FlyBase IDs
          References (2)