FlyBase Allele Report: Dmel\mtgo[UAS.RF]

General Information

Symbol

Dmel\mtgo^UAS.RF

Species

D. melanogaster

Name

FlyBase ID

FBal0345306

Feature type

allele

Associated gene

Dmel\mtgo

Associated Insertion(s)

Carried in Construct

M{UAS-mtgo.RF}

Key Links

Transgenic product class

cDNA

(Syed et al., 2019)

wild_type

(Syed et al., 2019)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Syed et al., 2019)

wild_type

(Syed et al., 2019)

Mutagen

in vitro construct

(Syed et al., 2019)

Progenitor genotype

Carried in construct

M{UAS-mtgo.RF}

Cytology

Description

UASt regulates expression of a full-length cDNA coding sequence for the mtgo-RF transcript. (The clone used (RE04201) contained a frameshift mutation that was corrected.)

(Syed et al., 2019)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

mtgo

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^arm.PS, mtgo^e02963

(Syed et al., 2019)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^arm.PS, mtgo^e02963

(Syed et al., 2019)

NMJ bouton | third instar larval stage, with Scer\GAL4^arm.PS, mtgo^e02963

(Syed et al., 2019)

Detailed Description

Statement

Reference

The expression of mtgo^UAS.RF under the control of Scer\GAL4^arm.PS rescues the neuromuscular defects observed in mtgo^e02963/mtgo^e02963, even leading to a significant increase in the number of boutons as compared to controls.

(Syed et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions