FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NpP6
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General Information
Symbol
Dmel\NpP6
Species
D. melanogaster
Name
FlyBase ID
FBal0345560
Feature type
allele
Associated gene
Dmel\Np
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Drees et al., 2019)
Mutagen
CRISPR/Cas9
(Drees et al., 2019)
Progenitor genotype
Cytology
Description

Frameshift mutation (14bp deletion) in the 5' region of the Np open reading frame.

(Drees et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:9,001,482..9,001,495 [-]
Comment:

A frameshift muation (14bp deletion) in the first coding exon of Np.

(Drees et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      NpP6 homozygous, NpC2/NpP6 transheterozygous and NpP6/Df(2R)BSC271 transheterozygous stage 17 embryos fail to clear liquid from the trachea. This defect is likely due to transepithelial barrier defects as, unlike in controls, a dye injected into the haemocoel of NpC2/NpP6 embryos diffuses into the tracheal lumen and is found in the paracellular space. NpC2/NpP6 embryos show taenidial fold defects with disorganized chitin strands, despite of a wild-type like tracheal tube morphology and a wild-type like epithelial polarity (as shown by the localization of Uninflatable, Crumbs, Megatrachea, Kune-kune and DE-cadherin).

      (Drees et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      NpP6 is a non-enhancer of embryonic/larval tracheal section | embryonic stage phenotype of pio17C

      (Drees et al., 2023)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      NpC2/NpP6 is rescued by Scer\GAL4btl.PS/NpUAS.cDa

      (Drees et al., 2019)
      Not rescued by

      NpC2/NpP6 is not rescued by Scer\GAL4btl.PS/NpS990A.UAS

      (Drees et al., 2019)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      NpP6
      (Drees et al., 2023, Drees et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)