FB2026_02 , released June 18, 2026
Allele: Dmel\Oseg41
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General Information
Symbol
Dmel\Oseg41
Species
D. melanogaster
Name
FlyBase ID
FBal0345591
Feature type
allele
Associated gene
Dmel\Oseg4
Associated Insertion(s)
TI{TI}Oseg41
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-out gene targeting
(Lee et al., 2018)
Progenitor genotype
Associated Insertion(s)
TI{TI}Oseg41
Cytology
Description

1kb of genomic sequence extending from the Oseg4 translation start site into the coding sequence has been deleted and replaced with a w+mW.hs marker.

(Lee et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Oseg41 mutants show ciliary transport defects in Johnston's organ chordotonal neurons: despite of no significant difference in the anterograde movement in proximal cilia, there is little to no anterograde movement in distal cilia or retrograde movement in proximal cilia, and retrograde motion in distal cilia is half the speed, as compared to controls. These neurons present no differences in the number, shape, or length of cilia, as compared to controls; despite the absence of paracrystalline inclusions in the ciliary dilations, the doublet microtubules of the 9+0 cilium and the cilia-cap connection seem normal, as compared to controls.

      Sound-evoked potentials recorded from antennal nerves are severely decreased compared to controls.

      (Lee et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Oseg41 is rescued by Scer\GAL4nan.PL/Oseg4UAS.cLa

      (Lee et al., 2018)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Oseg41
      (Lee et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)