FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RpS3NB
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General Information
Symbol
Dmel\RpS3NB
Species
D. melanogaster
Name
FlyBase ID
FBal0346176
Feature type
allele
Associated gene
Dmel\RpS3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - molecular evidence

    (Lee et al., 2018)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Contains four nucleotide substitutions compared to the reference sequence: one is intronic, two are predicted to be silent, but one mutates the ATG start codon to GTG, with no alternative ATG in frame from which RpS3 translation could be initiated.

    (Lee et al., 2018)

    Nucleotide substitution: A?G.

    (Lee et al., 2018)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:23,358,855..23,358,855 [+]
    Nucleotide change:

    A23358855G

    Reported nucleotide change:

    A?G

    Amino acid change:

    M1V | RpS3-PA; M1V | RpS3-PB

    Reported amino acid change:

    M1V

    Comment:

    Nucleotide substitution changes the ATG start codon to GTG. There are three other nucleotide substitutions in the mutant; one is in an intron and two are silent substitutions.

    (Lee et al., 2018)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        FlyBase curator comment: From correspondence with Nick Baker, "RpS3[NB]" likely corresponds to RpS3[2] (aka M(3)w[124]), available from Bloomington.

        (Lee et al., 2018)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        RpS3NB
        Name Synonyms
        Secondary FlyBase IDs
          References (1)