FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\perS942A.Tag:HA,Tag:polyHis
Open Close
General Information
Symbol
Dmel\perS942A.Tag:HA,Tag:polyHis
Species
D. melanogaster
Name
FlyBase ID
FBal0346256
Feature type
allele
Associated gene
Dmel\per
Associated Insertion(s)
Carried in Construct
P{per(S942A)-HA-10HIS}
Key Links
Transgenic product class
missense_variant
(Li et al., 2019)
polypeptide_post_translational_processing_variant
(Li et al., 2019)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Li et al., 2019)
polypeptide_post_translational_processing_variant
(Li et al., 2019)
Mutagen
in vitro construct
(Li et al., 2019)
Progenitor genotype
Carried in construct
P{per(S942A)-HA-10HIS}
Cytology
Description

13.2kb genomic fragment containing per. The coding sequence is tagged at the C-terminal end with Tag:HA and a stretch of 10 His residues. Amino acid residue S942A has been mutated to a non-O-GlcNAcylatable Ala residue.

(Li et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
per
Encoded product / tool
per
Tagged with
Tag:HA
Tag:polyHis
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      perS942A.Tag:HA,Tag:polyHis partially rescues per01

      (Li et al., 2019)
      Comments

      Expression of perS942A.Tag:HA,Tag:polyHis/+ or perS942A.Tag:HA,Tag:polyHis/perS942A.Tag:HA,Tag:polyHis in per01 background leads to shorter locomotor behavioral rhythms under constant dark condition (DD) compared to controls.

      Expression of perS942A.Tag:HA,Tag:polyHis in per01 adults leads to a robust feeding behavior with a phase advanced peak in LD while it fails to rescue the arrhythmic feeding behavior of per01 adults in DD.

      (Li et al., 2019)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      perS942A.Tag:HA,Tag:polyHis
      Name Synonyms
      Secondary FlyBase IDs
        References (1)