FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Arp14D2
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General Information
Symbol
Dmel\Arp14D2
Species
D. melanogaster
Name
FlyBase ID
FBal0346606
Feature type
allele
Associated gene
Dmel\Arp1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Nieuwburg et al., 2017)
Progenitor genotype
Cytology
Description

Amino acid replacement: E53K.

(Nieuwburg et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:12,692,813..12,692,813 [+]
Nucleotide change:

G12692813A

Amino acid change:

E53K | Arp1-PA

Reported amino acid change:

E53K

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Nieuwburg et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In Arp14D2 homozygotes the growing microtubule plus ends do not slow down close to the posterior region of the oocyte; very few plus ends extend into the posterior pole; and the lifespan of growing microtubule plus ends are reduced near the posterior cortex when compared to controls.

      (Nieuwburg et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      4D2
      (Nieuwburg et al., 2017)
      Arp14D2
      arp14D2-12
      (Nieuwburg et al., 2017)
      arp14D2
      (Nieuwburg et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)