FB2026_03 , released September 17, 2026
Allele: Dmel\Utxg.cd
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General Information
Symbol
Dmel\Utxg.cd
Species
D. melanogaster
Name
FlyBase ID
FBal0347246
Feature type
allele
Associated gene
Dmel\Utx
Associated Insertion(s)
Carried in Construct
M{gUtx.cd}
Key Links
Transgenic product class
missense_variant
(Copur and Müller, 2018)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Copur and Müller, 2018)
Mutagen
in vitro construct
(Copur and Müller, 2018)
Progenitor genotype
Carried in construct
M{gUtx.cd}
Cytology
Description

Genomic fragment (derived from BAC clone CH321-26E08) that encompasses the Utx gene. The coding sequence has been mutated to carry the amino acid substitutions H883A and G885A, resulting in a catalytically inactive protein.

(Copur and Müller, 2018)
Allele components
Component
Use(s)
Regulatory region(s)
Utx
Encoded product / tool
Utx
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults carrying the Utxg.cd allele in a UtxΔ/UtxΔ background derived from UtxΔ/+ mothers appear morphologically indistinguishable from wild-types, but die within 1-2 days post eclosion.

      (Copur and Müller, 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Utxg.cd fails to rescue UtxΔ

      (Copur and Müller, 2018)
      Comments

      Utxg.cd fails to rescue adult mortality in UtxΔ/UtxΔ flies derived from UtxΔ/+ mothers and larval lethality in UtxΔ/UtxΔ flies derived from UtxΔ/+ mothers with homozygous UtxΔ female germline clones.

      (Copur and Müller, 2018)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Utxg.cd
      Name Synonyms
      Secondary FlyBase IDs
        References (1)