FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\M6W186stop
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General Information
Symbol
Dmel\M6W186stop
Species
D. melanogaster
Name
FlyBase ID
FBal0349137
Feature type
allele
Associated gene
Dmel\M6
Associated Insertion(s)
Carried in Construct
Also Known As
M6W186*
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Wittek et al., 2020, Dunn et al., 2018)

amorphic allele - molecular evidence

(Wittek et al., 2020)
Mutagen
ethyl methanesulfonate
(Dunn et al., 2018)
Progenitor genotype
Cytology
Description

A premature stop codon in the third transmembrane domain, which truncates more than 40% of the protein.

(Dunn et al., 2018)

Amino acid replacement: W186term.

(Dunn et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:21,511,503..21,511,503 [+]
Nucleotide change:

G21511503A

Amino acid change:

W186term | M6-PB; W191term | M6-PC; W120term | M6-PD; W169term | M6-PE; W240term | M6-PF; W120term | M6-PG

Reported amino acid change:

W186term

Comment:

Reported amino acid change appears to be relative to M6-PB. G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Dunn et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  cancer
      modeled by Ras85DV12.cUa.UAS
      (Dunn et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      M6W186*
      (Zhao et al., 2025, Wittek et al., 2020, Dunn et al., 2018)
      M6W186Stop
      (Mira-Osuna et al., 2025)
      M6W186stop
      Name Synonyms
      Secondary FlyBase IDs
        References (4)