FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\IKKβCR
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General Information
Symbol
Dmel\IKKβCR
Species
D. melanogaster
Name
FlyBase ID
FBal0349276
Feature type
allele
Associated gene
Dmel\IKKβ
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Harris et al., 2018)
Progenitor genotype
Cytology
Description

1bp deletion of nucleotide 162 of the IKKβ cDNA, creating a frameshift mutation that results in a stop codon early in the kinase domain.

(Harris et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Motor neurons in either IKKβCR/IKKβCR or IKKβCR/Df(3R)BSC728 third instar larvae show a decrease in baseline neurotransmission, with mildly reduced mEPSP (mini excitatory postsynaptic potential) and EPSP (excitatory postsynaptic potential) amplitudes, but no change in quantal content compared to controls. IKKβCR/IKKβCR motor neurons display a similar mEPSP frequency as controls.

      Motor neurons in IKKβCR/IKKβCR third instar larvae display an increase in both active zone number and density, but a similar number of type I boutons as controls.

      (Harris et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Motor neurons in IKKβCR, GluRIIASP16 double mutant third instar larvae have further reduced mEPSP (mini excitatory postsynaptic potential) compared to single IKKβCR (but not GluRIIASP16) mutants; reduced EPSP (excitatory postsynaptic potential) amplitudes compared to either single mutant; and reduced quantal content compared to single GluRIIASP16 (but not IKKβCR) mutants. Their capacity for long-term presynaptic homeostatic plasticity (i.e. increase in quantal content causing an increase in EPSP amplitude, approaching baseline) is completely blocked.

      (Harris et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      IKKβCR
      (Harris et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)