FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ir52a3
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General Information
Symbol
Dmel\Ir52a3
Species
D. melanogaster
Name
FlyBase ID
FBal0349889
Feature type
allele
Associated gene
Dmel\Ir52a
Associated Insertion(s)
TI{TI}Ir52a3
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(He et al., 2019)
gene targeting by homologous recombination
(He et al., 2019)
Progenitor genotype
Associated Insertion(s)
TI{TI}Ir52a3
Cytology
Description

Deletion within Ir52a, removing codons specifying amino acid residues 31-447 (this includes two of the three predicted transmembrane domains and the predicted ligand binding domains). A loxP cassette containing the Disc\RFPDsRed(T1).3xP3.cHa marker has been inserted as part of the mutagenesis event.

(He et al., 2019)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ir52a3 males show defective courtship behavior and copulation: fewer initiate courtship behavior (i.e. wing extension) towards virgin females, and spend much less time on it, and fewer achieve successful copulation with virgin females, as compared to controls; courtship behavior initiation towards other males is also severely decreased, as compared to controls. There are no obvious locomotor defects in both genders as assessed by climbing assays, and males move at similar speeds as controls during courtship.

      Likewise, Ir52a3 females show a severe prolongation of the time to copulation and decreased frequency of copulation, despite of comparable courtship by paired males, as compared to controls.

      (He et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ir52a3
      (He et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)