FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CG9003indel
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General Information
Symbol
Dmel\CG9003indel
Species
D. melanogaster
Name
FlyBase ID
FBal0350185
Feature type
allele
Associated gene
Dmel\CG9003
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Meltzer et al., 2019)
Progenitor genotype
M{WKO.1-H5}
(Meltzer et al., 2019)
Cytology
Description

Indel mutation (4bp deletion, 74bp insertion) within the second coding exon of CG9003. The mutation is predicted to result in a truncated protein as the first 3 nucleotides of the 74bp insertion encode a TAA stop codon.

(Meltzer et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:11,644,946..11,644,949 [-]
Comment:

Inferred location of a 4bp deletion and 74bp insertion in the second coding exon of CG9003. The double strand break is reported as occurring 15 nucleotides downstream of the ATG for isoform CG9003- RC. The first three nucleotides of the inserted sequence encode a stop codon (TAA). The mapped location of the 4 base deletion is approximate.

(Meltzer et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      While mushroom body gamma neurons of CG9003indel homozygotes grow normally, adult mushroom bodies consistently display pruning defects.

      (Meltzer et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      CG9003indel has abnormal neuroanatomy | adult stage phenotype, enhanceable by slmb3A1/slmb[+]

      (Meltzer et al., 2019)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      CG9003indel has gamma Kenyon cell | adult stage phenotype, enhanceable by slmb3A1/slmb[+]

      (Meltzer et al., 2019)

      CG9003indel has axon | adult stage phenotype, enhanceable by slmb3A1/slmb[+]

      (Meltzer et al., 2019)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      CG9003indel homozygous adults show mushroom body gamma neuron pruning defects, which become more severe in a slmb3A1 heterozygous background.

      (Meltzer et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CG9003indel
      (Meltzer et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)