FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\usp3.UAS
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General Information
Symbol
Dmel\usp3.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0350235
Feature type
allele
Associated gene
Dmel\usp
Associated Insertion(s)
Carried in Construct
P{UAS-usp3}
Key Links
Transgenic product class
missense_variant
(Lee et al., 2019)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Lee et al., 2019)
Mutagen
in vitro construct
(Lee et al., 2019)
Progenitor genotype
Carried in construct
P{UAS-usp3}
Cytology
Description

UASt regulatory sequences drive expression of a mutated form of usp that carries the R160H amino acid substitution (the same lesion as found in usp3.

(Lee et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
usp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing usp3.UAS under the control of Scer\GAL4Crz.PU completely suppresses the death of vCrz peptidergic neurons at 6-7 hours after puparium formation.

      Expressing usp3.UAS under the control of Scer\GAL4CCAP.PP has no effect on CCAP neurons in third instar larvae, failing to cause premature cell death.

      In early pupae expressing usp3.UAS under the control of Scer\GAL4r4 fat bodies do not seem to be distributed to the head region, making it transparent. Also, normally granule-shaped fat bodies are not clearly developed.

      (Lee et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      usp3.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)