FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dywM2M1
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General Information
Symbol
Dmel\dywM2M1
Species
D. melanogaster
Name
FlyBase ID
FBal0350263
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
P{dmper/M2M1}
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

The P{dmpi8UP} construct, which contains wild type per regulatory regions and modified 5' and 3' splice sites (ss) of the per 'dmpi8' intron to increase its splicing efficiency, also contains the entire wild type dyw locus.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In 12:12 hour light:dark conditions, males and females carrying P{dmpi8UP} (in a per01 background) show significantly reduced daytime sleep levels compared to wild-type controls carrying P{dmpi8WT} (in a per01 background). The P{dmpi8UP}, per01 males and females also show reduced levels of sleep compared to controls when exposed to prolonged periods of constant light. The P{dmpi8UP} transgene contains both per and dyw coding sequences (represented in FlyBase by perM2M1 and dywM2M1 respectively); experiments using transgenes in which these coding sequences are individually or simultaneously mutated demonstrate that the reduced sleep phenotypes seen in P{dmpi8UP}, per01 flies are mediated via dyw function and not per function.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
dywM2M1
Name Synonyms
Secondary FlyBase IDs
    References (1)