FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\dyw
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General Information
Symbol
Dmel\dyw
Species
D. melanogaster
Name
daywake
Annotation Symbol
CG2650
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000092
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Summary
Component of the circadian clock or downstream effector of clock function (PubMed:2517256, PubMed:31080079). Required for suppressing daytime sleep (siesta) under ambient environmental temperatures. Part of a heat avoidance mechanism that modulates daytime sleep behavior under different environmental temperatures to minimize the risk of heat exposure. Under cooler ambient temperatures, suppresses daytime sleep (siesta) and thus allows for longer periods of daytime activity (PubMed:31080079). (UniProt, O76879)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

0.9, EG:155E2.1 , anon-3B1.2, 0.9kb transcript

Key Links
Genomic Location
Cytogenetic map
3B2-3B2
Sequence location
Recombination map
1-1.5
RefSeq locus
NC_004354 REGION:2692732..2693886
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in circadian rhythm
inferred from expression pattern
(Lorenz et al., 1989)
involved_in positive regulation of circadian sleep/wake cycle, wakefulness
inferred from mutant phenotype
(Yang and Edery, 2019)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in circadian rhythm
inferred from biological aspect of ancestor with PANTHER:PTN000865272
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN001663160
(GO Reference Genome Project, 2011-)
located_in extracellular space
inferred from sequence or structural similarity with FLYBASE:to; FB:FBgn0039298
(Dauwalder et al., 2002)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the TO family. (O76879)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Component of the circadian clock or downstream effector of clock function (PubMed:2517256, PubMed:31080079). Required for suppressing daytime sleep (siesta) under ambient environmental temperatures. Part of a heat avoidance mechanism that modulates daytime sleep behavior under different environmental temperatures to minimize the risk of heat exposure. Under cooler ambient temperatures, suppresses daytime sleep (siesta) and thus allows for longer periods of daytime activity (PubMed:31080079).
(UniProt, O76879)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\dyw for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O76879)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
dyw-RA
FBtr0070504
NM_130660
1013
260
Additional Transcript Data and Comments
Reported size (kB)

0.9 (northern blot)

(Pak et al., 1991, Reddy et al., 1984)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
dyw-PA
FBpp0070480
29.2
260
7.45
O76879
NP_570016
AAF45805
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

261 (aa)

(Pak et al., 1991)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dyw using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.45

Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
(Reddy et al., 1984)
epidermis
(Lorenz et al., 1989)
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
eye
(Xu et al., 2004)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
pupal stage
(Reddy et al., 1984)
Additional Descriptive Data

Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.

(Xu et al., 2004)

Levels of dyw transcripts are high in the epidermis of newly eclosed adults and decrease rapidly with age. Levels are not appreciable different in wild type and arrhythmic (per01) flies. dyw transcripts are also detected in late pupae. dyw expression is under circadian clock control.

(Pak et al., 1991)

The dyw transcript is expressed at low levels at the mid to late pupal stage, and transcript levels increase and persist through adult stages. In the adult, these dyw transcripts are expressed at high levels during the light period, and low levels during the dark period.

(Reddy et al., 1984)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\dyw in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of dyw
Transgenic constructs containing regulatory region of dyw
Aberrations (Deficiencies and Duplications) ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (0)
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (0)
Mus musculus (laboratory mouse) (0)
Xenopus tropicalis (Western clawed frog) (0)
Danio rerio (Zebrafish) (0)
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (19)
Agam\AgaP_AGAP004262
5 of 12
Yes
No
Agam\AgaP_AGAP004263
5 of 12
Yes
No
Agam\AgaP_AGAP012703
5 of 12
Yes
No
Agam\AgaP_AGAP009388
3 of 12
No
No
Agam\AgaP_AGAP013061
3 of 12
No
No
Agam\AgaP_AGAP000750
2 of 12
No
No
Agam\AgaP_AGAP001982
2 of 12
No
No
Agam\AgaP_AGAP001983
2 of 12
No
No
Agam\AgaP_AGAP001984
2 of 12
No
No
Agam\AgaP_AGAP011167
2 of 12
No
No
Agam\AgaP_AGAP001352
1 of 12
No
No
Agam\AgaP_AGAP001353
1 of 12
No
No
Agam\AgaP_AGAP001354
1 of 12
No
No
Agam\AgaP_AGAP001355
1 of 12
No
No
Agam\AgaP_AGAP001981
1 of 12
No
Yes
Agam\AgaP_AGAP008182
1 of 12
No
No
Agam\AgaP_AGAP009387
1 of 12
No
No
Agam\AgaP_AGAP012674
1 of 12
No
No
Agam\AgaP_AGAP013533
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:dyw. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (27)
Jhbp4
5 of 13
to
5 of 13
CG11854
4 of 13
CG14258
4 of 13
CG14259
4 of 13
CG31189
4 of 13
Jhbp2
4 of 13
Jhbp3
4 of 13
Jhbp5
4 of 13
Jhbp6
4 of 13
Jhbp7
4 of 13
Jhbp10
4 of 13
Jhbp12
4 of 13
Jhbp16
4 of 13
CG3246
3 of 13
CG7079
3 of 13
CG16820
3 of 13
CG31207
3 of 13
CG34316
3 of 13
Jhbp1
3 of 13
Jhbp11
3 of 13
Jhbp13
3 of 13
Jhbp14
3 of 13
Jhbp15
3 of 13
CG7968
1 of 13
CG8997
1 of 13
CG33306
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-1.5
    Cytogenetic map
    3B2-3B2
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    3B2-3B2
    Limits computationally determined from genome sequence between P{EP}EP1362 and P{EP}dncEP1395
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    1-1.5

    (FlyBase, 2016)

    1-1.2

    (Comeron et al., 2012)

    1-

    (Lorenz et al., 1989)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (4)
    Genomic Clones (21)
    cDNA Clones (10)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        "Gene order: Overall orientation not stated: per+ CG2650- CG2658- Csat-" was stated as revision.

        (Gatt and Ashburner, 2000.2.8)

        The direction of transcription reported in FBrf0040494 is in error.

        (Gatt and Ashburner, 2000.2.8)

        Quantifying rates of protein sequence divergence within and between species reveals that the Drosophila genome harbors a substantial proportion of genes with a very high divergence rate.

        (Schmid and Tautz, 1997)

        CG2650 becomes abundantly expressed during pupation, just prior to eclosion. In situ hybridization localizes the 0.9 kb transcript to the epidermis of newly eclosed adults. This RNA is transcribed from DNA adjacent to per and its expression is under circadian clock control. Expression of CG2650 appears to be under the control of the pupal circadian clock. The transcript is intensely expressed in late pupal development in individuals just hours away from eclosion, levels fall rapidly during the first few hours of adult life. Expression levels decrease with age, not time of day.

        (Lorenz et al., 1989)

        The level of CG2650 transcription is strongly modulated during light/dark cycles. CG2650 may be necessary but not sufficient to control arrays of cellular and rhythmic functions.

        (Reddy et al., 1984)

        Encodes 0.9kb RNA adjacent to per.

        (Zehring et al., 1984)
        Relationship to Other Genes
        Source for database merge of
        Additional comments
        Nomenclature History
        Source for database identify of

        Source for identity of: anon-3B1.2 CG2650

        (Deng, 1999.11)

        Source for identity of: dyw CG2650

        (Yang and Edery, 2019)
        Nomenclature comments
        Etymology

        Named 'daywake' as it functions as a day-specific suppressor of midday siesta.

        (Yang and Edery, 2019)
        Synonyms and Secondary IDs (13)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 155 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        References (51)