FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AtpαLNFS
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General Information
Symbol
Dmel\AtpαLNFS
Species
D. melanogaster
Name
FlyBase ID
FBal0351319
Feature type
allele
Associated gene
Dmel\Atpα
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Yang et al., 2019)
Progenitor genotype
Cytology
Description

Mutation within the first exon of Atpα that creates a frameshift which eliminates the long Atpα isoform while leaving the short isoform intact.

(Yang et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
3R:20,962,234..20,962,235 [+]
Nucleotide change:

AT20962234TC

Amino acid change:

Y15F | Atpalpha-PA

Reported amino acid change:

Y?F

Comment:

A two base substitution in the codon for aa 15 of isoform Atpalpha-PA leads to a Y to F amino acid change.

(Yang et al., 2019)
MNV
3R:20,962,234..20,962,235 [+]
Nucleotide change:

AT20962234TC

Reported nucleotide change:

AT?TC

Amino acid change:

Y15F | Atpalpha-PA

Reported amino acid change:

Y?F

Comment:

A two base substitution in the codon for aa 15 of isoform Atpalpha-PA leads to a Y to F amino acid change.

(Yang et al., 2019)
insertion
3R:20,962,246..20,962,247 [+]
Inserted_sequence:

C

Comment:

The insertion of a C between the two bases leads to a frameshift in the Atpalpha-PA isoform.

(Yang et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In the tracheal dorsal trunk of AtpαLNFS homozygous stage 16 embryos, the septate junctions are disrupted (revealed by Kune staining) and the tracheal tube length and diameter are increased, resulting in buckled and convoluted tubes, but there is no change in node cell diameter as compared to controls

      (Yang et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ATPαLNFS
      (Yang et al., 2019)
      AtpαLNFS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)