FlyBase Allele Report: Dmel\Opa1[UAS.cYa]

General Information

Symbol

Dmel\Opa1^UAS.cYa

Species

D. melanogaster

Name

UAS construct a of Yoon

FlyBase ID

FBal0351593

Feature type

allele

Associated gene

Dmel\Opa1

Associated Insertion(s)

Carried in Construct

P{UAS-Opa1.Y}

Also Known As

UAS Opa1

Key Links

Transgenic product class

wild_type

(Yoon et al., 2019)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Yoon et al., 2019)

Mutagen

in vitro construct

(Yoon et al., 2019)

Progenitor genotype

Carried in construct

P{UAS-Opa1.Y}

Cytology

Description

UASt regulates expression of Opa1.

(Yoon et al., 2019)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Opa1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^Mhc.PU

(Yoon et al., 2019)

viable, with Scer\GAL4^Mef2.PU

(Yoon et al., 2019)

Phenotype Manifest In

adult somatic muscle cell of thorax, with Scer\GAL4^Mhc.PU

(Yoon et al., 2019)

mitochondrion | adult stage, with Scer\GAL4^Mhc.PU

(Yoon et al., 2019)

Detailed Description

Statement

Reference

Adult flies expressing Opa1^UAS.cYa under the control of Scer\GAL4^Mhc.PU display unusual fragmented and rounded mitochondria in thoracic muscles, reduced locomotor activity and slower walking speed than controls.

(Yoon et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Opa1^UAS.cYa, Scer\GAL4^Mhc.PU has abnormal locomotor behavior | adult stage phenotype, non-enhanceable by Adck1^UAS.cYa, Scer\GAL4^Mhc.PU

(Yoon et al., 2019)

NOT suppressed by

Statement

Reference

Opa1^UAS.cYa, Scer\GAL4^Mhc.PU has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Adck1^UAS.cYa, Scer\GAL4^Mhc.PU

(Yoon et al., 2019)

Suppressor of

Statement

Reference

Opa1^UAS.cYa, Scer\GAL4^Mef2.PU is a suppressor of lethal - all die before end of P-stage phenotype of Adck1^UAS.cYa, Scer\GAL4^Mef2.PU

(Yoon et al., 2019)

Opa1^UAS.cYa, Scer\GAL4^Mhc.PU is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Adck1^UAS.cYa, Scer\GAL4^Mhc.PU

(Yoon et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Opa1^UAS.cYa, Scer\GAL4^Mhc.PU is a suppressor | partially of adult somatic muscle cell of thorax phenotype of Adck1^UAS.cYa, Scer\GAL4^Mhc.PU

(Yoon et al., 2019)

Opa1^UAS.cYa, Scer\GAL4^Mhc.PU is a suppressor | partially of mitochondrion | adult stage phenotype of Adck1^UAS.cYa, Scer\GAL4^Mhc.PU

(Yoon et al., 2019)

Other

Statement

Reference

Adck1^UAS.cYa, Opa1^UAS.cYa, Scer\GAL4^Mhc.PU has adult somatic muscle cell of thorax phenotype

(Yoon et al., 2019)

Adck1^UAS.cYa, Opa1^UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype

(Yoon et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Adult flies co-expressing Adck1^UAS.cYa and Opa1^UAS.cYa under the control of Scer\GAL4^Mhc.PU display unusual elongated and continuous mitochondria in thoracic muscles.

(Yoon et al., 2019)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Opa1^UAS.cYa

Name Synonyms

UAS construct a of Yoon

Secondary FlyBase IDs

References (3)

Report Sections

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